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In modern-day London, sixteen-year-old Miss James "Mori" Moriarty and classmate Sherlock Holmes set out to discover who is framing Mori for the Regent's Park killings.

Mori escapes captivity in the English countryside and returns to London, where she plots the downfall of her father and his cohorts but discovers that Lock may no longer be an ally.

Enola Holmes, now independent and pursuing her profession as a scientific perditorian, joins forces with her brother Sherlock to solve the mysterious disappearance of Wolcott Balestier, a friend of Rudyard Kipling, as they uncover the ruthless world of book publishing and seek to bring him back safely.