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After Detective Vincent Ruiz is removed from the Thames River with a bullet wound in his leg, he has no memory of the shooting.

Psychiatrist Joe O'Loughlin's life takes a dramatic turn when he is diagnosed with Parkinson's disease; but as he tries to cope with his fate, the police ask for his assistance in solving the murder of a nurse with whom he once worked not realizing that he would become a prime suspect.

Two teen girls disappear and are missing for three years when suddenly one of them is found dead.