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In 1934, during the Depression, Kit's cantankerous uncle comes to live in the Cincinnati boardinghouse run by her parents, enlisting her aid in transcribing his complaining letters to the editor of the local newspaper and inspiring her to write a different kind of letter of her own.

Montague Mad-Rat lives a solitary existance in the sewers of New York City.

When an electric fish shrinks Andrew, Judy, and Thudd to the size of bacteria, they end up being injected by a mosquito into Uncle Al's bloodstream where they must battle germs, parasites, and white blood cells.

While spending a month on an island off the coast of Washington helping in her Uncle Sanjay's veterinary clinic, eleven-year-old Poppy Ray soon questions her decision to follow in her uncle's footsteps.

In the mid-1950s, Lewis Barnavelt is convinced that a series of accidents that has been happening to him and his Uncle Jonathan are being directly caused by a curse from a mysterious, hooded figure that might be part of his uncle's past.

Kitty's owners are taking a week off and leaving Kitty and Puppy at home with Uncle Murray, and it isn't long before Uncle Murray is driven to near madness by shenanigans of epic proportions.

A boy and his uncle ride the teleferico to the top of a mountain in Venezuela.

When thirteen-year-old Dina emigrates from Germany to America in 1871, her only wish is to return home as soon as she can, but as the months pass and she survives a multitude of hardships living with her uncle and his young wife and baby, she finds herself thinking of Brooklyn as her home.

Uncle Herbert the Hare, the best hairdresser in town, has his hands full when his niece Holly spends time at his salon.

An eleven-year-old, bored with her life, imagines a more exciting one as a secret agent, but when she spends the summer on her aunt's farm, her stories become reality as she stumbles onto a real spy ring.

Fourth-grader Donavan is sensitive about the problems he has understanding math, and then when his favorite uncle, a former high school basketball star, returns from National Guard duty an amputee, Donavan's problems get even worse as he struggles to accept this "new" Uncle Vic.

Uncle Elephant comes to the rescue when his nephew's parents are lost at sea and cares for him until they are found again.

In a series of letters to his parents, Little Wolf describes his attempts to create "the scariest school in the world" and convince his ghostly Uncle Bigbad to teach a magic class.

The fearsome knight Horace tries to prove to his niece that he is as good as his brother, the King, while all she really wants is someone to help her stop missing her father.

After being teased about his brand new loafers, Rigo puts them away for so long he grows out of them.